InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASMTL

Summary

InnateDB Protein

IDBP-39971.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASMTL

Protein Name

acetylserotonin O-methyltransferase-like

Synonyms

ASMTLX; ASMTLY; ASTML;

Species

Homo sapiens

Ensembl Protein

ENSP00000370734

InnateDB Gene

IDBG-39967 (ASMTL)

Protein Structure

UniProt Annotation

Function

Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008171	O-methyltransferase activity

Biological Process

GO:0008150	biological_process
GO:0032259	methylation

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001077 O-methyltransferase, family 2
IPR003697 Maf-like protein
IPR029001 Inosine triphosphate pyrophosphatase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00891
PF02545

PRINTS

PIRSF

PIRSF006305

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95671