Version 5.4
Mus musculus Protein: Uspl1
Summary
InnateDB Protein IDBP-400106.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Uspl1
Protein Name ubiquitin specific peptidase like 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113176
InnateDB Gene IDBG-209339 (Uspl1)
Protein Structure
UniProt Annotation
Function SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, Cajal body {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0032183 SUMO binding
GO:0070140 SUMO-specific isopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008283 cell proliferation
GO:0016926 protein desumoylation
GO:0030576 Cajal body organization
Cellular Component
GO:0015030 Cajal body
Protein Structure and Domains
PDB ID MGI:2442342
InterPro IPR028889 Ubiquitin carboxyl-terminal hydrolase-like domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ULM6
PhosphoSite PhosphoSite-Q3ULM6
TrEMBL D3Z5G1
UniProt Splice Variant
Entrez Gene 231915
UniGene Mm.457818
RefSeq NP_001108623
MGI ID
MGI Symbol Uspl1
OMIM
CCDS CCDS51705
HPRD
IMGT
EMBL AC122546 AK050969 AK088787 AK145409 AK161654 BC028849 BC086664
GenPept AAH28849 AAH86664 BAC34481 BAE26422 BAE36513 BAE43395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca