InnateDB Protein
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IDBP-400110.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ano1
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Protein Name
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anoctamin 1, calcium activated chloride channel
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Synonyms
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Tmem16a;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112616
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InnateDB Gene
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IDBG-212921 (Ano1)
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Protein Structure
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Function |
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. {ECO:0000269PubMed:18585372, ECO:0000269PubMed:18724360, ECO:0000269PubMed:21908539, ECO:0000269PubMed:22002868, ECO:0000269PubMed:22075693}.
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Subcellular Localization |
Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles. {ECO:0000269PubMed:18585372, ECO:0000269PubMed:18724360, ECO:0000269PubMed:20056604}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005227
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calcium activated cation channel activity
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GO:0005229
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intracellular calcium activated chloride channel activity
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GO:0005515
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protein binding
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GO:0042803
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protein homodimerization activity
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GO:0046982
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protein heterodimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2142149
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InterPro |
IPR007632
Anoctamin
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PFAM |
PF04547
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BHY3
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PhosphoSite |
PhosphoSite-Q8BHY3
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TrEMBL |
D3YYA4
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UniProt Splice Variant |
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Entrez Gene |
101772
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UniGene |
Mm.437507
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RefSeq |
NP_848757
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MGI ID |
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MGI Symbol |
Ano1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC122336
AC149593
AC153792
AK028991
AK029329
AK052589
BC006062
BC062959
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GenPept |
AAH06062
AAH62959
BAC26230
BAC26398
BAC35051
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