InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr1d

Summary

InnateDB Protein

IDBP-400126.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr1d

Protein Name

5-hydroxytryptamine (serotonin) receptor 1D

Synonyms

5-HT-1D; 5-HT1D; AI853647; Gpcr14; Htr1db;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112402

InnateDB Gene

IDBG-198024 (Htr1d)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in the motor column in spinal cord, and in several cranial motor nuclei, including nucleus ambiguous, oculomotoris, trochelaris and abducens. Detected in gamma motor neurons in the lumbar spinal cord. Detected in proprioceptive sensory neurons in dorsal root ganglia. {ECO:0000269PubMed:22273508}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0051378	serotonin binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0009636	response to toxic substance
GO:0014827	intestine smooth muscle contraction
GO:0040012	regulation of locomotion
GO:0042310	vasoconstriction
GO:0050795	regulation of behavior

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96276

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000505 5-Hydroxytryptamine 1D receptor
IPR002147 5-Hydroxytryptamine 1B receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00514
PR00513
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61224