InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgfr2

Summary

InnateDB Protein

IDBP-400165.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfr2

Protein Name

fibroblast growth factor receptor 2

Synonyms

AU043015; AW556123; Bek; Fgfr-2; Fgfr-7; Fgfr7; KGFR; KGFRTr; svs;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113180

InnateDB Gene

IDBG-210753 (Fgfr2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017134	fibroblast growth factor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001837	epithelial to mesenchymal transition
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003148	outflow tract septum morphogenesis
GO:0003149	membranous septum morphogenesis
GO:0006468	protein phosphorylation
GO:0007267	cell-cell signaling
GO:0007409	axonogenesis
GO:0007528	neuromuscular junction development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008589	regulation of smoothened signaling pathway
GO:0009791	post-embryonic development
GO:0009880	embryonic pattern specification
GO:0009887	organ morphogenesis
GO:0010453	regulation of cell fate commitment
GO:0010518	positive regulation of phospholipase activity
GO:0016331	morphogenesis of embryonic epithelium
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0022612	gland morphogenesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0030324	lung development
GO:0030855	epithelial cell differentiation
GO:0030901	midbrain development
GO:0030916	otic vesicle formation
GO:0031069	hair follicle morphogenesis
GO:0032808	lacrimal gland development
GO:0035264	multicellular organism growth
GO:0035265	organ growth
GO:0040014	regulation of multicellular organism growth
GO:0040036	regulation of fibroblast growth factor receptor signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042472	inner ear morphogenesis
GO:0042476	odontogenesis
GO:0045165	cell fate commitment
GO:0045839	negative regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048286	lung alveolus development
GO:0048333	mesodermal cell differentiation
GO:0048489	synaptic vesicle transport
GO:0048557	embryonic digestive tract morphogenesis
GO:0048562	embryonic organ morphogenesis
GO:0048565	digestive tract development
GO:0048568	embryonic organ development
GO:0048608	reproductive structure development
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048730	epidermis morphogenesis
GO:0048755	branching morphogenesis of a nerve
GO:0048762	mesenchymal cell differentiation
GO:0050673	epithelial cell proliferation
GO:0050678	regulation of epithelial cell proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051150	regulation of smooth muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060174	limb bud formation
GO:0060348	bone development
GO:0060349	bone morphogenesis
GO:0060365	coronal suture morphogenesis
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060442	branching involved in prostate gland morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060449	bud elongation involved in lung branching
GO:0060463	lung lobe morphogenesis
GO:0060484	lung-associated mesenchyme development
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060512	prostate gland morphogenesis
GO:0060523	prostate epithelial cord elongation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0060601	lateral sprouting from an epithelium
GO:0060615	mammary gland bud formation
GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060667	branch elongation involved in salivary gland morphogenesis
GO:0060670	branching involved in labyrinthine layer morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060688	regulation of morphogenesis of a branching structure
GO:0060915	mesenchymal cell differentiation involved in lung development
GO:0060916	mesenchymal cell proliferation involved in lung development
GO:0061031	endodermal digestive tract morphogenesis
GO:0070307	lens fiber cell development
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:95523

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

PIRSF000628

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References