InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYC1

Summary

InnateDB Protein

IDBP-40017.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYC1

Protein Name

cytochrome c-1

Synonyms

MC3DN6; UQCR4;

Species

Homo sapiens

Ensembl Protein

ENSP00000317159

InnateDB Gene

IDBG-40015 (CYC1)

Protein Structure

UniProt Annotation

Function

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.

Subcellular Localization

Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side.

Disease Associations

Mitochondrial complex III deficiency, nuclear 6 (MC3DN6) [MIM:615453]: An autosomal recessive disorder caused by mitochondrial dysfunction. It is characterized by onset in early childhood of episodic acute lactic acidosis, ketoacidosis, and insulin-responsive hyperglycemia, usually associated with infection. Laboratory studies show decreased activity of mitochondrial complex III. Psychomotor development is normal. {ECO:0000269PubMed:23910460}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0045155	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity

Biological Process

GO:0022904	respiratory electron transport chain
GO:0033762	response to glucagon
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070469	respiratory chain