Version 5.4
| Mus musculus Protein: Hcrtr1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-400182.4 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Hcrtr1 | ||||||||
| Protein Name | hypocretin (orexin) receptor 1 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000112630 | ||||||||
| InnateDB Gene | IDBG-192481 (Hcrtr1) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed. {ECO:0000269PubMed:15256537}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2385650 | ||||||||
| InterPro |
IPR000204
Orexin receptor family IPR000276 G protein-coupled receptor, rhodopsin-like IPR000611 Neuropeptide Y receptor family IPR004059 Orexin receptor 1 IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
||||||||
| PFAM |
PF00001
PF10320 |
||||||||
| PRINTS |
PR01064
PR00237 PR01012 PR01521 |
||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P58307 | ||||||||
| PhosphoSite | PhosphoSite-P58307 | ||||||||
| TrEMBL | Q0VDP6 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 230777 | ||||||||
| UniGene | Mm.246595 | ||||||||
| RefSeq | XP_006503122 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Hcrtr1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18707 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF394596 AK140137 AL606925 AY255599 AY336083 BC119582 BC119583 CU207372 CU210846 | ||||||||
| GenPept | AAI19583 AAI19584 AAK71326 AAO85111 AAR01326 BAE24252 CAM45913 CAQ51584 CAQ51833 | ||||||||