Version 5.4
Mus musculus Protein: Rabgef1
Summary
InnateDB Protein IDBP-400210.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rabgef1
Protein Name RAB guanine nucleotide exchange factor (GEF) 1
Synonyms Rab5ef; Rabex5; Rin2;
Species Mus musculus
Ensembl Protein ENSMUSP00000112537
InnateDB Gene IDBG-202259 (Rabgef1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0002686 negative regulation of leukocyte migration
GO:0016567 protein ubiquitination
GO:0033004 negative regulation of mast cell activation
GO:0043305 negative regulation of mast cell degranulation
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0050728 negative regulation of inflammatory response
GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 negative regulation of interleukin-6 secretion
GO:1900235 negative regulation of Kit signaling pathway
Cellular Component
GO:0031982 vesicle
Protein Structure and Domains
PDB ID MGI:1929459
InterPro IPR002653 Zinc finger, A20-type
PFAM PF01754
PRINTS
PIRSF
SMART SM00259
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YWB4
UniProt Splice Variant
Entrez Gene 56715
UniGene Mm.474835
RefSeq
MGI ID
MGI Symbol Rabgef1
OMIM
CCDS
HPRD
IMGT
EMBL AC113029 AC122339
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca