InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rabgef1

Summary

InnateDB Protein

IDBP-400212.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rabgef1

Protein Name

RAB guanine nucleotide exchange factor (GEF) 1

Synonyms

Rab5ef; Rabex5; Rin2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114103

InnateDB Gene

IDBG-202259 (Rabgef1)

Protein Structure

UniProt Annotation

Function

Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A (By similarity). Can act as a ubiquitin ligase (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the white matter tracts of the cerebellum, the fimbria hippocampi and the corpus callosum. {ECO:0000269PubMed:10926822}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0002686	negative regulation of leukocyte migration
GO:0006897	endocytosis
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0033004	negative regulation of mast cell activation
GO:0043305	negative regulation of mast cell degranulation
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050728	negative regulation of inflammatory response
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165	negative regulation of interleukin-6 secretion
GO:1900235	negative regulation of Kit signaling pathway