InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2e3

Summary

InnateDB Protein

IDBP-400242.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2e3

Protein Name

ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast)

Synonyms

Ubce4; ubcM2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113463

InnateDB Gene

IDBG-183144 (Ube2e3)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest. {ECO:0000250, ECO:0000269PubMed:14993279}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	87 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0040008	regulation of growth
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination