InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbx3

Summary

InnateDB Protein

IDBP-400307.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbx3

Protein Name

T-box 3

Synonyms

D5Ertd189e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112519

InnateDB Gene

IDBG-195379 (Tbx3)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.

Disease Associations

Tissue Specificity

In adults, highest levels in lung. Also found in brain, heart, kidney, liver and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003167	atrioventricular bundle cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007569	cell aging
GO:0008284	positive regulation of cell proliferation
GO:0008595	anterior/posterior axis specification, embryo
GO:0009887	organ morphogenesis
GO:0010159	specification of organ position
GO:0019827	stem cell maintenance
GO:0021761	limbic system development
GO:0030539	male genitalia development
GO:0030540	female genitalia development
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030879	mammary gland development
GO:0032275	luteinizing hormone secretion
GO:0035108	limb morphogenesis
GO:0035115	embryonic forelimb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0042127	regulation of cell proliferation
GO:0042733	embryonic digit morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0045662	negative regulation of myoblast differentiation
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046884	follicle-stimulating hormone secretion
GO:0048332	mesoderm morphogenesis
GO:0055007	cardiac muscle cell differentiation
GO:0060021	palate development
GO:0060412	ventricular septum morphogenesis
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0060596	mammary placode formation
GO:0060923	cardiac muscle cell fate commitment
GO:0060931	sinoatrial node cell development
GO:0090398	cellular senescence
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:98495

InterPro

IPR001699 Transcription factor, T-box
IPR002070 Transcription factor, Brachyury
IPR008967 p53-like transcription factor, DNA-binding
IPR022582 Transcription factor, T-box, region of unknown function

PFAM

PF00907
PF12598

PRINTS

PR00937
PR00938

PIRSF

SMART

SM00425

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt