Mus musculus Protein: Disc1
Summary
InnateDB Protein IDBP-400327.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Disc1
Protein Name disrupted in schizophrenia 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000112593
InnateDB Gene IDBG-200561 (Disc1)
Protein Structure
UniProt Annotation
Function Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269PubMed:17825401, ECO:0000269PubMed:19303846, ECO:0000269PubMed:19502360, ECO:0000269PubMed:19778506}.
Subcellular Localization Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Colocalizes with PCNT at the centrosome. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in granule cell precursors within the dentate migratory stream during the first week of postnatal life and in differentiated granule cells of the hippocampus (at protein level). Expressed in dentate gyrus, hippocampus and in the olfactory bulb. {ECO:0000269PubMed:17825401, ECO:0000269PubMed:19502360}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 115 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0002052 positive regulation of neuroblast proliferation
GO:0008104 protein localization
GO:0010975 regulation of neuron projection development
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021846 cell proliferation in forebrain
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031929 TOR signaling
GO:0034613 cellular protein localization
GO:0051560 mitochondrial calcium ion homeostasis
GO:0060070 canonical Wnt signaling pathway
GO:0090128 regulation of synapse maturation
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005874 microtubule
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0036064 ciliary basal body
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:2447658
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q811T9
PhosphoSite PhosphoSite-Q811T9
TrEMBL
UniProt Splice Variant
Entrez Gene 244667
UniGene Mm.233504
RefSeq
MGI ID
MGI Symbol Disc1
OMIM
CCDS
HPRD
IMGT
EMBL AF513723 AF513724 AJ506179 AJ506180 AY177673 AY320287
GenPept AAN77091 AAN77092 AAO19641 AAP83943 CAD44629 CAD44630