Version 5.4
Mus musculus Protein: Ccdc64
Summary
InnateDB Protein IDBP-400329.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccdc64
Protein Name coiled-coil domain containing 64
Synonyms 2210403N09Rik; BICDR-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000114133
InnateDB Gene IDBG-194308 (Ccdc64)
Protein Structure
UniProt Annotation
Function Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis. {ECO:0000269PubMed:20360680}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:20360680}. Note=Localizes around the centrosome.
Disease Associations
Tissue Specificity Highly expressed during early embryonic development. Predominantly expressed in kidney, undifferentiated neural tissue and developing eye. {ECO:0000269PubMed:20360680}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 26 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0034452 dynactin binding
Biological Process
GO:0031175 neuron projection development
GO:0055107 Golgi to secretory granule transport
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Protein Structure and Domains
PDB ID MGI:1922915
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0JNT9
PhosphoSite PhosphoSite-A0JNT9
TrEMBL
UniProt Splice Variant
Entrez Gene 75665
UniGene Mm.233914
RefSeq
MGI ID
MGI Symbol Ccdc64
OMIM
CCDS
HPRD
IMGT
EMBL AK036757 AK041990 BC024804 BC126948
GenPept AAH24804 AAI26949 BAC29565 BAC31124

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca