InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mgst1

Summary

InnateDB Protein

IDBP-400385.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgst1

Protein Name

microsomal glutathione S-transferase 1

Synonyms

1500002K10Rik; Gst;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113859

InnateDB Gene

IDBG-195593 (Mgst1)

Protein Structure

UniProt Annotation

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000250}.

Subcellular Localization

Microsome {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0010243	response to organonitrogen compound
GO:0032496	response to lipopolysaccharide
GO:0033327	Leydig cell differentiation
GO:0042493	response to drug
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071449	cellular response to lipid hydroperoxide

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell