InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Emcn

Summary

InnateDB Protein

IDBP-400392.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Emcn

Protein Name

endomucin

Synonyms

0610012K22Rik; AI315669; Muc14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112603

InnateDB Gene

IDBG-195850 (Emcn)

Protein Structure

UniProt Annotation

Function

Endothelial sialomucin, also called endomucin or mucin- like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in heart and kidney, followed by brain, spleen, thymus, liver and lung. Exclusively expressed in endothelial cells. {ECO:0000269PubMed:11418125}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030246	carbohydrate binding

Biological Process

GO:0001525	angiogenesis
GO:0016337	single organismal cell-cell adhesion
GO:0030155	regulation of cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1891716

InterPro

IPR010740 Endomucin

PFAM

PF07010

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R0H2

PhosphoSite

PhosphoSite-Q9R0H2

TrEMBL

UniProt Splice Variant

Entrez Gene

59308

UniGene

Mm.414987

RefSeq

NP_001156994

MGI ID

MGI Symbol

Emcn

OMIM

CCDS

CCDS51075

HPRD

IMGT

EMBL

AB034693 AB034694 AF060883 AK002616 BC003706

GenPept

AAD05208 AAH03706 BAA86226 BAA86227 BAB22232