InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OSM

Summary

InnateDB Protein

IDBP-4004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OSM

Protein Name

oncostatin M

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215781

InnateDB Gene

IDBG-4002 (OSM)

Protein Structure

UniProt Annotation

Function

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005147	oncostatin-M receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0006955	immune response
GO:0007275	multicellular organismal development
GO:0007422	peripheral nervous system development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0040008	regulation of growth
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042506	tyrosine phosphorylation of Stat5 protein
GO:0042508	tyrosine phosphorylation of Stat1 protein
GO:0043410	positive regulation of MAPK cascade
GO:0045835	negative regulation of meiosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046888	negative regulation of hormone secretion
GO:0048266	behavioral response to pain
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051781	positive regulation of cell division
GO:2001235	positive regulation of apoptotic signaling pathway