Version 5.4
Mus musculus Protein: Lrrc8d
Summary
InnateDB Protein IDBP-400473.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lrrc8d
Protein Name leucine rich repeat containing 8D
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113603
InnateDB Gene IDBG-186113 (Lrrc8d)
Protein Structure
UniProt Annotation
Function Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes in the endoplasmic reticulum. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1922368
InterPro IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR021040 Leucine-rich repeat-containing protein 8, N-terminal
PFAM PF00560
PF13504
PF13855
PF12534
PRINTS
PIRSF
SMART SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGR2
PhosphoSite PhosphoSite-Q8BGR2
TrEMBL D3Z6C1
UniProt Splice Variant
Entrez Gene 231549
UniGene Mm.475310
RefSeq NP_848816
MGI ID
MGI Symbol Lrrc8d
OMIM
CCDS CCDS19494
HPRD
IMGT
EMBL AC122566 AC137107 AK046249 AK050400 AK080722 AK137459 BC037717
GenPept AAH37717 BAC32656 BAC34237 BAC37994 BAE23361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca