InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Furin

Summary

InnateDB Protein

IDBP-400506.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Furin

Protein Name

furin (paired basic amino acid cleaving enzyme)

Synonyms

9130404I01Rik; Fur; PACE; Pcsk3; SPC1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113370

InnateDB Gene

IDBG-195335 (Furin)

Protein Structure

UniProt Annotation

Function

Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Seems to be expressed ubiquitously.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0042277	peptide binding
GO:0046872	metal ion binding
GO:0048406	nerve growth factor binding

Biological Process

GO:0006465	signal peptide processing
GO:0006508	proteolysis
GO:0008283	cell proliferation
GO:0009966	regulation of signal transduction
GO:0010951	negative regulation of endopeptidase activity
GO:0016485	protein processing
GO:0016486	peptide hormone processing
GO:0019058	viral life cycle
GO:0032804	negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902	nerve growth factor production
GO:0032911	negative regulation of transforming growth factor beta1 production
GO:0032940	secretion by cell
GO:0042176	regulation of protein catabolic process
GO:0043043	peptide biosynthetic process
GO:0052548	regulation of endopeptidase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005788	endoplasmic reticulum lumen
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0012510	trans-Golgi network transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97513

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR006212 Furin-like repeat
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR015500 Peptidase S8, subtilisin-related

PFAM

PF00082
PF01483

PRINTS

PR00723

PIRSF

SMART

SM00261

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt