Version 5.4
Mus musculus Protein: Edc4
Summary
InnateDB Protein IDBP-400539.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Edc4
Protein Name enhancer of mRNA decapping 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113854
InnateDB Gene IDBG-188958 (Edc4)
Protein Structure
UniProt Annotation
Function In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro) (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, P-body {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2446249
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UJB9
PhosphoSite PhosphoSite-Q3UJB9
TrEMBL
UniProt Splice Variant
Entrez Gene 234699
UniGene Mm.28979
RefSeq NP_853625
MGI ID
MGI Symbol Edc4
OMIM
CCDS CCDS52662
HPRD
IMGT
EMBL AK146527 AK152963 BC022641 BC053081
GenPept AAH22641 AAH53081 BAE27236 BAE31626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca