Version 5.4
Mus musculus Protein: Cxcl10
Summary
InnateDB Protein IDBP-400583.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cxcl10
Protein Name chemokine (C-X-C motif) ligand 10
Synonyms C7; CRG-2; gIP-10; Ifi10; INP10; IP-10; IP10; mob-1; Scyb10;
Species Mus musculus
Ensembl Protein ENSMUSP00000114134
InnateDB Gene IDBG-179916 (Cxcl10)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 2 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
GO:0048248 CXCR3 chemokine receptor binding
Biological Process
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0009306 protein secretion
GO:0009409 response to cold
GO:0010332 response to gamma radiation
GO:0010996 response to auditory stimulus
GO:0016525 negative regulation of angiogenesis
GO:0030816 positive regulation of cAMP metabolic process
GO:0033280 response to vitamin D
GO:0034605 cellular response to heat
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045087 innate immune response (InnateDB)
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0060326 cell chemotaxis
GO:0071222 cellular response to lipopolysaccharide
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:1352450
InterPro IPR001089 CXC chemokine
IPR001811 Chemokine interleukin-8-like domain
PFAM PF00048
PRINTS PR00437
PIRSF
SMART SM00199
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3YW23
UniProt Splice Variant
Entrez Gene 15945
UniGene Mm.877
RefSeq
MGI ID
MGI Symbol Cxcl10
OMIM
CCDS
HPRD
IMGT
EMBL AC122365
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca