Version 5.4
Mus musculus Protein: Syn3
Summary
InnateDB Protein IDBP-400601.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Syn3
Protein Name synapsin III
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113720
InnateDB Gene IDBG-181964 (Syn3)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0007269 neurotransmitter secretion
GO:0008152 metabolic process
Cellular Component
GO:0008021 synaptic vesicle
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:1351334
InterPro IPR001359 Synapsin
IPR013651 ATP-grasp fold, RimK-type
IPR016185 Pre-ATP-grasp domain
IPR019736 Synapsin, phosphorylation site
IPR020897 Synapsin, pre-ATP-grasp domain
IPR020898 Synapsin, ATP-binding domain
PFAM PF08443
PF10581
PF02078
PF02750
PRINTS PR01368
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8JZP2
PhosphoSite PhosphoSite-Q8JZP2
TrEMBL
UniProt Splice Variant
Entrez Gene 27204
UniGene Mm.444873
RefSeq NP_038750
MGI ID
MGI Symbol Syn3
OMIM
CCDS CCDS24096
HPRD
IMGT
EMBL AC122919 AC124614 AC125060 AC145076 AC150899 AF498252 AF498253
GenPept AAM22969 AAM22970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca