InnateDB Protein
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IDBP-400638.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pde4d
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Protein Name
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phosphodiesterase 4D, cAMP specific
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113488
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InnateDB Gene
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IDBG-181732 (Pde4d)
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Protein Structure
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Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Apical cell membrane {ECO:0000250}. Note=Colocalized with SHANK2 to the apical membrane of colonic crypt cells (By similarity). Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain (at protein level). Isoform 7 is detected in heart, brain, lung, kidney and testis. {ECO:0000269PubMed:12834813, ECO:0000269PubMed:17244609}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
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Biological Process |
GO:0002027
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regulation of heart rate
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GO:0006198
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cAMP catabolic process
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GO:0006939
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smooth muscle contraction
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GO:0007165
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signal transduction
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GO:0007568
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aging
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GO:0010880
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regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
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GO:0030593
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neutrophil chemotaxis
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GO:0032729
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positive regulation of interferon-gamma production
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GO:0032743
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positive regulation of interleukin-2 production
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GO:0032754
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positive regulation of interleukin-5 production
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GO:0033137
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negative regulation of peptidyl-serine phosphorylation
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GO:0035264
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multicellular organism growth
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GO:0045822
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negative regulation of heart contraction
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GO:0050852
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T cell receptor signaling pathway
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GO:0050900
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leukocyte migration
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GO:0060314
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regulation of ryanodine-sensitive calcium-release channel activity
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GO:0061028
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establishment of endothelial barrier
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GO:0071222
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cellular response to lipopolysaccharide
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GO:0071320
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cellular response to cAMP
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GO:0071872
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cellular response to epinephrine stimulus
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GO:0086004
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regulation of cardiac muscle cell contraction
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GO:1901844
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regulation of cell communication by electrical coupling involved in cardiac conduction
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GO:1901898
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negative regulation of relaxation of cardiac muscle
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Cellular Component |
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PDB ID |
MGI:99555
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InterPro |
IPR002073
3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR023088
3\'5\'-cyclic nucleotide phosphodiesterase
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PFAM |
PF00233
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PRINTS |
PR00387
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q01063
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PhosphoSite |
PhosphoSite-Q01063
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TrEMBL |
A6XDA7
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UniProt Splice Variant |
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Entrez Gene |
238871
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UniGene |
Mm.485166
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RefSeq |
NP_035186
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MGI ID |
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MGI Symbol |
Pde4d
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OMIM |
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CCDS |
CCDS49359
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HPRD |
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IMGT |
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EMBL |
AC161585
AC163650
AF536978
AK081466
AY388962
BC132107
BC132109
CH466568
CT025605
DQ665892
DQ665893
DQ665894
M94541
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GenPept |
AAA37368
AAI32108
AAI32110
AAN10120
AAQ90406
ABG57273
ABG57274
ABG57275
BAC38226
CAQ51656
EDL18440
EDL18441
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