InnateDB Protein
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IDBP-400650.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Kif2a
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Protein Name
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kinesin family member 2A
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Synonyms
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C530030B14Rik; Kif2; Kns2; M-kinesin;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112715
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InnateDB Gene
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IDBG-181060 (Kif2a)
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Protein Structure
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Function |
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9774330}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9774330}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:9774330}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Lysosome {ECO:0000269PubMed:9774330}. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1 (By similarity). Associated with lysosomes in NIH3T3 cells. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level). Isoform 1 expressed in neuronal cells. Isoform 2 expressed in astrocytes and fibroblasts. {ECO:0000269PubMed:9774330}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:108390
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InterPro |
IPR001752
Kinesin, motor domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
P28740
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PhosphoSite |
PhosphoSite-P28740
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
16563
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UniGene |
Mm.471008
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RefSeq |
NP_032468
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MGI ID |
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MGI Symbol |
Kif2a
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OMIM |
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CCDS |
CCDS26759
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HPRD |
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IMGT |
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EMBL |
BC006803
D12644
Y15894
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GenPept |
AAH06803
BAA02165
CAA75815
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