InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Magi3

Summary

InnateDB Protein

IDBP-400654.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Magi3

Protein Name

membrane associated guanylate kinase, WW and PDZ domain containing 3

Synonyms

4732496O19Rik; 6530407C02Rik; AA407180; AI120132; mKIAA1634;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113713

InnateDB Gene

IDBG-182565 (Magi3)

Protein Structure

UniProt Annotation

Function

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269PubMed:15195140, ECO:0000269PubMed:15652357}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15195140}; Peripheral membrane protein {ECO:0000269PubMed:15195140}. Cell junction, tight junction {ECO:0000269PubMed:15195140}. Nucleus {ECO:0000250}. Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Colocalizes with TGFA in neurons in the cortex and dentate gyrus, as well as in ependymal cells and some astrocytes (at protein level). Present in lens epithelium. {ECO:0000269PubMed:14645510, ECO:0000269PubMed:15652357}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0043507

positive regulation of JUN kinase activity

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction

Protein Structure and Domains

PDB ID

MGI:1923484

InterPro

IPR001202 WW domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00397
PF00595
PF13180
PF00625

PRINTS

PIRSF

SMART

SM00456
SM00228
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EQJ9