InnateDB Protein
|
IDBP-400660.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Sult1b1
|
Protein Name
|
sulfotransferase family 1B, member 1
|
Synonyms
|
ST1B1; St2b2;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000112844
|
InnateDB Gene
|
IDBG-176070 (Sult1b1)
|
Protein Structure
|
|
Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates L-DOPA and D-DOPA, tyrosine isomers such as DL-m-tyrosine, dopamine and thyroid hormones. {ECO:0000269PubMed:9644246}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Liver specific. {ECO:0000269PubMed:9644246}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:2136282
|
InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
|
PFAM |
PF00685
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9QWG7
|
PhosphoSite |
PhosphoSite-Q9QWG7
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
56362
|
UniGene |
Mm.23502
|
RefSeq |
XP_006535213
|
MGI ID |
|
MGI Symbol |
Sult1b1
|
OMIM |
|
CCDS |
CCDS19391
|
HPRD |
|
IMGT |
|
EMBL |
AF022894
AK033498
AK087595
BC024361
U92076
|
GenPept |
AAD01746
AAD09249
AAH24361
BAC28321
BAC39939
|
|
|