InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sult1b1

Summary

InnateDB Protein

IDBP-400661.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sult1b1

Protein Name

sulfotransferase family 1B, member 1

Synonyms

ST1B1; St2b2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112679

InnateDB Gene

IDBG-176070 (Sult1b1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates L-DOPA and D-DOPA, tyrosine isomers such as DL-m-tyrosine, dopamine and thyroid hormones. {ECO:0000269PubMed:9644246}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Liver specific. {ECO:0000269PubMed:9644246}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004062	aryl sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0009812	flavonoid metabolic process
GO:0042403	thyroid hormone metabolic process
GO:0051923	sulfation