InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taf1

Summary

InnateDB Protein

IDBP-400664.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf1

Protein Name

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112772

InnateDB Gene

IDBG-164335 (Taf1)

Protein Structure

UniProt Annotation

Function

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004402	histone acetyltransferase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0016573	histone acetylation

Cellular Component

GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0045120	pronucleus
GO:0071339	MLL1 complex

Protein Structure and Domains

PDB ID

MGI:1336878

InterPro

IPR001487 Bromodomain
IPR009067 TAFII-230 TBP-binding
IPR011177 Transcription initiation factor TFIID subunit 1, animal
IPR022591 Transcription initiation factor TFIID subunit 1, domain of unknown function

PFAM

PF00439
PF09247
PF12157

PRINTS

PR00503

PIRSF

PIRSF003047

SMART

SM00297

TIGRFAMs

Post-translational Modifications

Modification

Cross-References