Version 5.4
Mus musculus Protein: Tmprss11d
Summary
InnateDB Protein IDBP-400690.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmprss11d
Protein Name transmembrane protease, serine 11d
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113079
InnateDB Gene IDBG-175319 (Tmprss11d)
Protein Structure
UniProt Annotation
Function May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions (By similarity). Plays a role in the proteolytic processing of ACE2. Isoform 2 may play a key role in regulating adrenal proliferation by specifically cleaving N-POMC. {ECO:0000250, ECO:0000269PubMed:24227843}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Transmembrane protease serine 11D catalytic chain: Secreted {ECO:0000250}. Note=Activated by cleavage and secreted. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the esophagus, tongue, and trachea, low expression was seen in heart, lung, and adrenal gland. Isoform 2 is also highly expressed in the adrenal gland. {ECO:0000269PubMed:14691009}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID MGI:2385221
InterPro IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
PFAM PF00089
PF09342
PRINTS PR00722
PIRSF
SMART SM00020
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VHK8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 231382
UniGene Mm.422376
RefSeq
MGI ID 2E7V
MGI Symbol Tmprss11d
OMIM
CCDS
HPRD
IMGT
EMBL AB053953 AF448809 AF539752 BC020151
GenPept AAH20151 AAL47139 AAP97729 BAD89353

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca