Version 5.4
Mus musculus Protein: Gjb1
Summary
InnateDB Protein IDBP-400698.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gjb1
Protein Name gap junction protein, beta 1
Synonyms AI118175; Cnx32; Cx32; Gjb-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000113516
InnateDB Gene IDBG-163754 (Gjb1)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005243 gap junction channel activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0007154 cell communication
GO:0015868 purine ribonucleotide transport
GO:0051259 protein oligomerization
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:95719
InterPro IPR000500 Connexin
IPR002267 Gap junction beta-1 protein (Cx32)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PR01138
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28230
PhosphoSite PhosphoSite-P28230
TrEMBL
UniProt Splice Variant
Entrez Gene 14618
UniGene
RefSeq XP_006527888
MGI ID
MGI Symbol Gjb1
OMIM
CCDS CCDS30314
HPRD
IMGT
EMBL AJ271753 BC026833 M63802 M81447
GenPept AAA37296 AAA37496 AAH26833 CAB72446

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca