InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Naip6

Summary

InnateDB Protein

IDBP-400769.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Naip6

Protein Name

NLR family, apoptosis inhibitory protein 6

Synonyms

Birc1f; Birc1g; Naip-rs4; Naip-rs4A; Naip-rs4B; Naip6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112867

InnateDB Gene

IDBG-262560 (Naip6)

Protein Structure

UniProt Annotation

Function

Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals. {ECO:0000269PubMed:21874021}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0016045	detection of bacterium
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0070269	pyroptosis
GO:0071391	cellular response to estrogen stimulus

Cellular Component

GO:0072557

IPAF inflammasome complex

Protein Structure and Domains

PDB ID

MGI:1298222

InterPro

IPR001370 Baculoviral inhibition of apoptosis protein repeat
IPR007111 NACHT nucleoside triphosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00653

PRINTS

PIRSF

SMART

SM00238

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JIB6