InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gng7

Summary

InnateDB Protein

IDBP-400785.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gng7

Protein Name

guanine nucleotide binding protein (G protein), gamma 7

Synonyms

AI840417;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113798

InnateDB Gene

IDBG-176606 (Gng7)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum. {ECO:0000269PubMed:12488442}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Brain. Found in the hippocampus, striatum, midbrain and cortex. {ECO:0000269PubMed:12488442}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity

Biological Process

GO:0001662	behavioral fear response
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007626	locomotory behavior
GO:0045761	regulation of adenylate cyclase activity