InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmgcs2

Summary

InnateDB Protein

IDBP-400825.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmgcs2

Protein Name

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

Synonyms

1300002P16; mHS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113296

InnateDB Gene

IDBG-177864 (Hmgcs2)

Protein Structure

UniProt Annotation

Function

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004421	hydroxymethylglutaryl-CoA synthase activity

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008152	metabolic process
GO:0008299	isoprenoid biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

MGI:101939

InterPro

IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal
IPR016039 Thiolase-like

PFAM

PF01154
PF08540

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54869

PhosphoSite