InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chaf1b

Summary

InnateDB Protein

IDBP-400826.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chaf1b

Protein Name

chromatin assembly factor 1, subunit B (p60)

Synonyms

2600017H24Rik; C76145; CAF-I p60; CAF-Ip60; CAF1; CAF1A; CAF1P60; MPHOSPH7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113684

InnateDB Gene

IDBG-178301 (Chaf1b)

Protein Structure

UniProt Annotation

Function

Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=DNA replication foci. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0031497	chromatin assembly

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0033186	CAF-1 complex

Protein Structure and Domains

PDB ID

MGI:1314881

InterPro

IPR001632 G-protein, beta subunit
IPR001680 WD40 repeat
IPR013979 Translation initiation factor, beta propellor-like domain
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF08662

PRINTS

PR00319

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt