InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Papd5

Summary

InnateDB Protein

IDBP-400830.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Papd5

Protein Name

PAP associated domain containing 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112608

InnateDB Gene

IDBG-178589 (Papd5)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly expressed in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0004652	polynucleotide adenylyltransferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006364	rRNA processing
GO:0006397	mRNA processing
GO:0007067	mitotic nuclear division
GO:0071044	histone mRNA catabolic process