Version 5.4
Mus musculus Protein: Trip4
Summary
InnateDB Protein IDBP-400844.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trip4
Protein Name thyroid hormone receptor interactor 4
Synonyms 4930558E03Rik; ASC-1; Asc1; BB191711;
Species Mus musculus
Ensembl Protein ENSMUSP00000112866
InnateDB Gene IDBG-178421 (Trip4)
Protein Structure
UniProt Annotation
Function Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B (By similarity). Plays a role in androgen receptor transactivation and testicular function. {ECO:0000250, ECO:0000269PubMed:12390891}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Cytoplasmic under conditions of serum deprivation. Co- localizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:12390891}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016922 ligand-dependent nuclear receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
Protein Structure and Domains
PDB ID MGI:1928469
InterPro IPR007374 ASCH domain
IPR009349 Zinc finger, C2HC5-type
IPR015947 PUA-like domain
PFAM PF04266
PF06221
PRINTS
PIRSF
SMART SM01022
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QXN3
PhosphoSite PhosphoSite-Q9QXN3
TrEMBL Q3UBZ2
UniProt Splice Variant
Entrez Gene 56404
UniGene Mm.488827
RefSeq NP_001164378
MGI ID
MGI Symbol Trip4
OMIM
CCDS CCDS52838
HPRD
IMGT
EMBL AC151906 AF197574 AF539614 AK039024 AK150752 BC021316
GenPept AAF18440 AAH21316 AAN23117 BAC30209 BAE29822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca