Version 5.4
Mus musculus Protein: Zwilch
Summary
InnateDB Protein IDBP-400889.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zwilch
Protein Name Zwilch, kinetochore associated, homolog (Drosophila)
Synonyms 2310031L18Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000112790
InnateDB Gene IDBG-175909 (Zwilch)
Protein Structure
UniProt Annotation
Function Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (By similarity). {ECO:0000250}.
Subcellular Localization Chromosome, centromere, kinetochore {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0007093 mitotic cell cycle checkpoint
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
Protein Structure and Domains
PDB ID MGI:1915264
InterPro IPR018630 RZZ complex, subunit zwilch
PFAM PF09817
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R060
PhosphoSite PhosphoSite-Q8R060
TrEMBL H3BKZ0
UniProt Splice Variant
Entrez Gene 68014
UniGene Mm.474670
RefSeq NP_080783
MGI ID
MGI Symbol Zwilch
OMIM
CCDS CCDS23275
HPRD
IMGT
EMBL AC114674 AC160118 AK009559 AK019825 BC027435 CH466522
GenPept AAH27435 BAB26358 BAB31869 EDL26055

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca