InnateDB Protein
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IDBP-400896.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Brcc3
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Protein Name
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BRCA1/BRCA2-containing complex, subunit 3
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000114057
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InnateDB Gene
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IDBG-157387 (Brcc3)
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Protein Structure
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Function |
Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
35 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2389572
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InterPro |
IPR000555
JAB1/MPN/MOV34 metalloenzyme domain
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PFAM |
PF01398
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PRINTS |
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PIRSF |
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SMART |
SM00232
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TIGRFAMs |
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Modification |
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SwissProt |
P46737
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PhosphoSite |
PhosphoSite-P46737
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TrEMBL |
E9Q0P6
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UniProt Splice Variant |
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Entrez Gene |
210766
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UniGene |
Mm.416059
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RefSeq |
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MGI ID |
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MGI Symbol |
Brcc3
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK011876
AK149844
AL671860
BC021313
BC048179
S68022
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GenPept |
AAB29006
AAH21313
AAH48179
BAB27894
BAE29117
CAM46071
CAP19082
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