InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Skor1

Summary

InnateDB Protein

IDBP-400910.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Skor1

Protein Name

SKI family transcriptional corepressor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113924

InnateDB Gene

IDBG-175143 (Skor1)

Protein Structure

UniProt Annotation

Function

Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1. {ECO:0000250, ECO:0000269PubMed:15528197}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15528197}.

Disease Associations

Tissue Specificity

Expressed in brain with higher levels in embryo than adult. Expressed by migratory precursors of Purkinje cells in the postnatal brain. Also expressed in adult testis. {ECO:0000269PubMed:15528197, ECO:0000269PubMed:17292623}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514	negative regulation of BMP signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated