InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF207

Summary

InnateDB Protein

IDBP-40092.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF207

Protein Name

zinc finger protein 207

Synonyms

BuGZ;

Species

Homo sapiens

Ensembl Protein

ENSP00000322777

InnateDB Gene

IDBG-40088 (ZNF207)

Protein Structure

UniProt Annotation

Function

Kinetochore-binding protein involved in spindle-assembly checkpoint signaling by regulating mitotic chromosome alignment and mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269PubMed:24462186, ECO:0000269PubMed:24462187}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	23 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0006355	regulation of transcription, DNA-templated
GO:0007094	mitotic spindle assembly checkpoint
GO:0008608	attachment of spindle microtubules to kinetochore
GO:0050821	protein stabilization
GO:0051983	regulation of chromosome segregation