InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacna1a

Summary

InnateDB Protein

IDBP-400932.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna1a

Protein Name

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Synonyms

alpha1A; APCA; BI; Caca1a; Cacnl1a4; Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352; rkr; SCA6; tg;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114055

InnateDB Gene

IDBG-174190 (Cacna1a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	89 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006006	glucose metabolic process
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007270	neuron-neuron synaptic transmission
GO:0007274	neuromuscular synaptic transmission
GO:0007416	synapse assembly
GO:0007628	adult walking behavior
GO:0014051	gamma-aminobutyric acid secretion
GO:0014056	regulation of acetylcholine secretion
GO:0016049	cell growth
GO:0017156	calcium ion-dependent exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0019226	transmission of nerve impulse
GO:0021522	spinal cord motor neuron differentiation
GO:0021590	cerebellum maturation
GO:0021679	cerebellar molecular layer development
GO:0021680	cerebellar Purkinje cell layer development
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021750	vestibular nucleus development
GO:0021953	central nervous system neuron differentiation
GO:0030644	cellular chloride ion homeostasis
GO:0032353	negative regulation of hormone biosynthetic process
GO:0034765	regulation of ion transmembrane transport
GO:0035249	synaptic transmission, glutamatergic
GO:0042133	neurotransmitter metabolic process
GO:0042391	regulation of membrane potential
GO:0042445	hormone metabolic process
GO:0043113	receptor clustering
GO:0043524	negative regulation of neuron apoptotic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0048791	calcium ion-dependent exocytosis of neurotransmitter
GO:0048813	dendrite morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050877	neurological system process
GO:0050883	musculoskeletal movement, spinal reflex action
GO:0050885	neuromuscular process controlling balance
GO:0050905	neuromuscular process
GO:0051899	membrane depolarization
GO:0055085	transmembrane transport
GO:0060024	rhythmic synaptic transmission
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:109482

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005448 Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01632

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt