Mus musculus Protein: Cadm2
Summary
InnateDB Protein IDBP-400972.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cadm2
Protein Name cell adhesion molecule 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113178
InnateDB Gene IDBG-170806 (Cadm2)
Protein Structure
UniProt Annotation
Function Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein. Cell junction, synapse {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Found in the axoplasm of myelinated axons. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007420 brain development
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0032809 neuronal cell body membrane
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:2442722
InterPro IPR003585 Neurexin/syndecan/glycophorin C
IPR003597 Immunoglobulin C1-set
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set
PFAM PF07654
PF07679
PF07686
PF00047
PF08205
PRINTS
PIRSF
SMART SM00294
SM00407
SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLQ9
PhosphoSite PhosphoSite-Q8BLQ9
TrEMBL
UniProt Splice Variant
Entrez Gene 239857
UniGene Mm.404648
RefSeq NP_001139449
MGI ID 3M45
MGI Symbol Cadm2
OMIM
CCDS CCDS49885
HPRD
IMGT
EMBL AC105980 AC109233 AC154196 AC154428 AC154674 AK033973 AK038842 AK043760 AK046800 BC139401 BC139402 CT010571
GenPept AAI39402 AAI39403 BAC28533 BAC30148 BAC31646 BAC32876 CAP19089 CAP19090