InnateDB Protein
|
IDBP-401028.4
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Hs3st1
|
Protein Name
|
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
|
Synonyms
|
3-Ost; D5Wsu110e; Hsg3ost;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000113919
|
InnateDB Gene
|
IDBG-160451 (Hs3st1)
|
Protein Structure
|
|
Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. {ECO:0000269PubMed:9346953}.
|
Subcellular Localization |
Golgi apparatus lumen {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0008146
|
sulfotransferase activity
|
GO:0008467
|
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1201606
|
InterPro |
IPR000863
Sulfotransferase domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
|
PFAM |
PF00685
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O35310
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
D3YZM3
|
UniProt Splice Variant |
|
Entrez Gene |
15476
|
UniGene |
Mm.427791
|
RefSeq |
XP_006503809
|
MGI ID |
3UAN
|
MGI Symbol |
Hs3st1
|
OMIM |
|
CCDS |
CCDS19257
|
HPRD |
|
IMGT |
|
EMBL |
AC098713
AC144779
AF019385
AK087753
BC009133
|
GenPept |
AAB84387
AAH09133
BAC39991
|
|
|