InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Reep1

Summary

InnateDB Protein

IDBP-401152.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Reep1

Protein Name

receptor accessory protein 1

Synonyms

D6Ertd253e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112662

InnateDB Gene

IDBG-156152 (Reep1)

Protein Structure

UniProt Annotation

Function

Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=A small proportion is detected at the cell surface. {ECO:0000269PubMed:15550249}.

Disease Associations

Tissue Specificity

Detected in olfactory sensory neurons of the olfactory epithelium, and in total brain. {ECO:0000269PubMed:15550249}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0031849	olfactory receptor binding

Biological Process

GO:0032386	regulation of intracellular transport
GO:0051205	protein insertion into membrane
GO:0071786	endoplasmic reticulum tubular network organization

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane