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InnateDB Protein
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IDBP-401160.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Serpina10
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Protein Name
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serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113644
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InnateDB Gene
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IDBG-167240 (Serpina10)
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Protein Structure
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| Function |
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Secreted {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Detectable in liver, but not in heart, brain, spleen, lung, kidney, skeletal muscle or testes. {ECO:0000269PubMed:11372680}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
0
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| Protein-DNA |
0
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| Protein-RNA |
1
[view]
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
4 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0004867
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serine-type endopeptidase inhibitor activity
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GO:0008201
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heparin binding
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:2667725
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| InterPro |
IPR023796
Serpin domain
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| PFAM |
PF00079
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| PRINTS |
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| PIRSF |
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| SMART |
SM00093
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q8R121
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
217847
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| UniGene |
Mm.29094
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| RefSeq |
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| MGI ID |
4AJT
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| MGI Symbol |
Serpina10
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AY324633
BC018416
BC025821
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| GenPept |
AAH18416
AAH25821
AAP87100
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Version 5.4