Version 5.4
Mus musculus Protein: Sycn
Summary
InnateDB Protein IDBP-401168.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sycn
Protein Name syncollin
Synonyms 0910001K16Rik; 1810038B08Rik; SYL;
Species Mus musculus
Ensembl Protein ENSMUSP00000112770
InnateDB Gene IDBG-394170 (Sycn)
Protein Structure
UniProt Annotation
Function Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. {ECO:0000269PubMed:11839820, ECO:0000269PubMed:15040787, ECO:0000269PubMed:15462671}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Note=Localizes to zymogen granules. Associated with lipid rafts in a cholesterol-dependent manner. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006887 exocytosis
Cellular Component
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
Protein Structure and Domains
PDB ID MGI:1915666
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VCK7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 68416
UniGene
RefSeq NP_080992
MGI ID
MGI Symbol Sycn
OMIM
CCDS CCDS21048
HPRD
IMGT
EMBL AK003083 BC019567
GenPept AAH19567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca