InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbs

Summary

InnateDB Protein

IDBP-401215.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbs

Protein Name

cystathionine beta-synthase

Synonyms

AI047524; AI303044; HIP4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113209

InnateDB Gene

IDBG-164615 (Cbs)

Protein Structure

UniProt Annotation

Function

Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004122	cystathionine beta-synthase activity
GO:0020037	heme binding
GO:0030170	pyridoxal phosphate binding
GO:0030554	adenyl nucleotide binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0072341	modified amino acid binding

Biological Process

GO:0001958	endochondral ossification
GO:0001974	blood vessel remodeling
GO:0006535	cysteine biosynthetic process from serine
GO:0006565	L-serine catabolic process
GO:0006801	superoxide metabolic process
GO:0019343	cysteine biosynthetic process via cystathionine
GO:0019344	cysteine biosynthetic process
GO:0019346	transsulfuration
GO:0019448	L-cysteine catabolic process
GO:0021587	cerebellum morphogenesis
GO:0030823	regulation of cGMP metabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043418	homocysteine catabolic process
GO:0043506	regulation of JUN kinase activity
GO:0050667	homocysteine metabolic process
GO:0050880	regulation of blood vessel size
GO:0051593	response to folic acid
GO:0060135	maternal process involved in female pregnancy
GO:0060351	cartilage development involved in endochondral bone morphogenesis
GO:0070814	hydrogen sulfide biosynthetic process
GO:0071456	cellular response to hypoxia