InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spock3

Summary

InnateDB Protein

IDBP-401247.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spock3

Protein Name

sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3

Synonyms

2900045C01Rik; AI428471; mKIAA4039;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113683

InnateDB Gene

IDBG-157981 (Spock3)

Protein Structure

UniProt Annotation

Function

May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005539	glycosaminoglycan binding
GO:0008191	metalloendopeptidase inhibitor activity

Biological Process

GO:0007165	signal transduction
GO:0010951	negative regulation of endopeptidase activity
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan