InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Palld

Summary

InnateDB Protein

IDBP-401255.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Palld

Protein Name

palladin, cytoskeletal associated protein

Synonyms

2410003B16Rik; 6030492A02;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112374

InnateDB Gene

IDBG-157412 (Palld)

Protein Structure

UniProt Annotation

Function

Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific May be required for the initiation of neural tube closure. {ECO:0000269PubMed:10931874, ECO:0000269PubMed:15950489, ECO:0000269PubMed:16492705, ECO:0000269PubMed:17115415}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:10931874}. Cell junction, focal adhesion {ECO:0000269PubMed:10931874}. Cell projection, ruffle {ECO:0000269PubMed:10931874}. Cell projection, lamellipodium {ECO:0000269PubMed:10931874}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269PubMed:10931874}. Note=Localizes to stress fibers and Z lines.

Disease Associations

Tissue Specificity

Detected in both muscle and non-muscle tissues and cells (at protein level). Isoform 3 is widely expressed, isoform 4 is particularly abundant in tissues rich in smooth muscle and in the cardiac muscle and isoform 1 is detected in heart. {ECO:0000269PubMed:10931874, ECO:0000269PubMed:11438925}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005884	actin filament
GO:0005925	focal adhesion
GO:0030018	Z disc
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

MGI:1919583

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ET54