InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfrc

Summary

InnateDB Protein

IDBP-401280.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfrc

Protein Name

transferrin receptor

Synonyms

2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; Mtvr-1; Mtvr1; p90; TFR; TFR1; TR; Trfr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113028

InnateDB Gene

IDBG-154429 (Tfrc)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004998	transferrin receptor activity
GO:0005381	iron ion transmembrane transporter activity
GO:0005515	protein binding
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006879	cellular iron ion homeostasis
GO:0006898	receptor-mediated endocytosis
GO:0034755	iron ion transmembrane transport

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98822

InterPro

IPR003137 Protease-associated domain, PA
IPR007484 Peptidase M28

PFAM

PF02225
PF04389

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q8C872

UniProt Splice Variant

Entrez Gene

22042

UniGene

Mm.408555

RefSeq

MGI ID

MGI Symbol

Tfrc

OMIM

CCDS

HPRD

IMGT

EMBL

AC161755 AK048228 CH466521

GenPept

BAC33277 EDK97800