InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Auh

Summary

InnateDB Protein

IDBP-401283.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Auh

Protein Name

AU RNA binding protein/enoyl-coenzyme A hydratase

Synonyms

C77140; W91705;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112427

InnateDB Gene

IDBG-152823 (Auh)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:10072761}.

Disease Associations

Tissue Specificity

Detected in heart, brain, liver, spleen, skeletal muscle and kidney. {ECO:0000269PubMed:10072761}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0003824	catalytic activity
GO:0004300	enoyl-CoA hydratase activity
GO:0004490	methylglutaconyl-CoA hydratase activity

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006552	leucine catabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1338011

InterPro

IPR001753 Crotonase superfamily
IPR029045 ClpP/crotonase-like domain

PFAM

PF00378

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLZ3

PhosphoSite

PhosphoSite-Q9JLZ3

TrEMBL

UniProt Splice Variant

Entrez Gene

11992

UniGene

Mm.490957

RefSeq

MGI ID

MGI Symbol

Auh

OMIM

CCDS

HPRD

IMGT

EMBL

AF118386 AK003929 AK019978 BC026525 BC049597

GenPept

AAF28835 AAH26525 AAH49597 BAB23078 BAB31947